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25 Best CBD Gummies for Erectile Dysfunction For 2022 CBD can interact with many medications, including sildenafil (Viagra). Read on to learn if you can take CBD oil together with Viagra. Cannabidiol or CBD may prolong the effects of sildenafil (Viagra) — but is this combination safe? What are the risks?

25 Best CBD Gummies for Erectile Dysfunction For 2022

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If you’re suffering from erectile dysfunction and need a way to chill out the nerves while getting the blood pumping through your penis then look no further. This list of the 25 best CBD gummies for erectile dysfunction is your answer.

We’re featuring the best gummies to help reduce stress and anxiety all the while helping boost your penis girth for the big event. Whether you’ve been suffering from erectile dysfunction for years or new to this issue, we’re confident that these CBD gummies for erectile dysfunction will surely help you start enjoying sex more often with a hard penis.

Delta North Delta-8 Gummies

Bearly Legal Hemp Co Delta-8 Gummies

Equilibria Daily Gummies

Exhale Wellness CBD Gummies

Just CBD Gummies

Budpop CBD + Ashwagandha Gummies

Cheef Botanicals CBD Gummy Cubes

Hollyweed CBD Cube Gummies

Fab CBD Gummies

Hemp Bombs CBD Gummies

CBDistillery 30mg Broad Spectrum CBD Anytime Gummies

Royal CBD Broad Spectrum CBD Gummies 25mg

Rocky River Hemp CBD Gummies

In case you didn’t know, erectile dysfunction (ED) is something that about 52% of men between the ages of 40 and 70 experience. This is something that’s estimated to impact over 322 million people globally by the ear 2025.

Since so many men experience this problem, we wanted to feature products that help discreetly. One of the best options to try to help your ED is CBD. This is a chemical that’s derived from the cannabis plant and is increasing in popularity year by year.

Much research has been completed to show that CBD gummies for erectile dysfunction can help with anxiety and stress to improve your mood. While we can’t find 100% evidence out there noted that CBD can improve ED, we’ve found many people have experienced less erectile dysfunction issxues when taking CBD gummies regularly.

We can only assume that the CBD helps calm the nerves of people with mild versions of ED. If your erectile dysfunction is caused by a medical issue or something else that’s major, then the best CBD gummies for erectile dysfunction may not help improve your situation.

What is CBD?

CBD, or cannabidiol, is a compound found in cannabis and hemp. CBD can be extracted from these plants to create an oil, which can be consumed on its own or infused into products like gummies.

CBD has become popular in recent years as more people explore its potential health benefits. Some people use CBD to help with conditions like pain, anxiety, and insomnia. Others use it to improve their skin health or boost their energy levels.

What are CBD gummies?

CBD gummies are a type of edible that contains the compound CBD. Gummies are a popular type of CBD edibles as they are easy to consume, have a long shelf life, and come in a variety of flavors.

CBD gummies are often made with full-spectrum CBD oil, which contains all of the compounds found in the hemp plant. This includes trace amounts of THC, terpenes, and other cannabinoids.

Full-spectrum CBD gummies may provide a more potent effect than broad-spectrum or isolate CBD gummies as the compounds work together to provide a synergistic effect.

CBD gummies are typically safe and well-tolerated. Some people may experience minor side effects like dry mouth, fatigue, or changes in appetite. These side effects are usually temporary and resolve on their own.

If you’re interested in trying CBD gummies for erectile dysfunction, there are many different products available, including gummies. When choosing a CBD product, it’s important to do your research and select a high-quality product from a reputable brand.

How to Choose the Best CBD Gummies for Erectile Dysfunction

When it comes to CBD gummies, there are a lot of options to choose from. But with so many brands and products on the market, how do you know which ones are the best?

Here are a few things to look for when choosing CBD gummies to improve your sex life:

Make sure the brand uses high-quality CBD.

This is the most important factor in choosing CBD gummies. Look for brands that use CBD that has been third-party lab tested for purity and potency.

Choose a brand that offers a variety of CBD gummies.

This way, you can find the perfect product for your needs. Some brands offer gummies with different flavors, dosages, and ingredients.

Pick a brand that uses natural ingredients.

CBD gummies made with all-natural ingredients are always the best choice. Avoid brands that use artificial flavors, colors, or sweeteners.

Choose a company that has transparency about their products.

The best CBD gummies come from companies that are transparent about their manufacturing process and ingredients. Look for brands that provide clear information about their products.

Now that you know what to look for, here are the 25 best CBD gummies for erectile dysfunction:

1. Penguin CBD Full Spectrum Gummies

Image courtesy Penguin CBD

Penguin CBD gummies are made with full spectrum CBD oil, and contain no artificial flavors or colors. Each gummy contains 10 mg of CBD, and there are 30 gummies per bottle. These are by far the best CBD gummies for erectile dysfunction featured here today!

2. Everest Full Spectrum Gummies

Image courtesy Everest

Everest Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. There are 30 gummies per bottle. Everest Gummies are vegan, and non-GMO. As of right now Everest has citrus flavored vegan gummies available for help with erectile dysfunction.

3. R+R Medicinals Gummies

Image courtesy R+R Medicinals

R+R Medicinals CBD gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. R+R Medicinals gummies are also vegan and non-GMO.

4. Leaf Remedys CBD Gummies

Image courtesy Leaf Remedys

Leaf Remedys CBD Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Leaf Remedys’ gummies are also vegan and non-GMO.

5. Colorado Botanicals Gummies

Image courtesy Colorado Botanicals

Colorado Botanicals Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Colorado Botanicals’ gummies are also vegan and non-GMO.

6. FOCL’s Premium Full-Spectrum CBD Gummies

FOCL’s Premium Full-Spectrum CBD Gummies are the easiest way to provide your body with overall wellness, whether at home or on-the-go. They not only taste like a treat, they’re also highly effective at relaxing the body and mind, and made with only the highest quality organic ingredients. With 25mg of Premium Full-Spectrum CBD in each gummy, they really pack a punch. They’re also vegan, non-GMO, and come in 3 delicious flavors (Sour Watermelon, Mandarin Orange & Tropical Punch). FOCL offers free shipping on every order as well as bundle pack options. Enjoy maximum relief with FOCL’s delicious Full-Spectrum CBD Gummies. Made with extracts from the whole hemp plant to give you the deepest possible benefits.

7. Verma Farms CBD gummies

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Verma Farms CBD gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Verma Farms’ gummies are also vegan and non-GMO.

8. Medterra Keep Calm CBD Gummies

Image courtesy Medterra

Medterra Keep Calm CBD Gummies are made with full spectrum CBD oil and chamomile flower extract, and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Medterra’s gummies are also vegan and non-GMO.

9. Joy Organics CBD Gummies

Image courtesy Joy Organics

Joy Organics CBD Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Joy Organics’ gummies are also vegan and non-GMO.

10. cbdMD Tropical CBD Gummies

Image courtesy cbdMD

cbdMD Tropical CBD Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. cbdMD’s gummies are also vegan and non-GMO.

11. Batch CBD Full-Spectrum Gummies

Batch has been praised among the industry for top quality products. Founded by chemists with a passion to bring natural alternatives to their customers, Batch crafted their CBD gummies with all natural ingredients and juicy fruity flavor. With 25mg of CBD in each square, these gummies are sure to help you feel your best.

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12. Delta North Delta-8 Gummies

Image courtesy Delta North

Delta-8 Gummies are made with CBD oil that has been isolated to only contain the delta-8 THC compound. Delta-8 THC is a less psychoactive form of THC, and these gummies contain no more than 0.3% delta-9 THC.

Each gummy contains 25 mg of Delta-8 THC, and there are 30 gummies per bottle. Delta-8 Gummies are vegan, and non-GMO.

13. Bearly Legal Hemp Co Delta-8 Gummies

Image courtesy Bearly Legal Hemp Co

Bearly Legal Hemp Co.’s Delta-8 Gummies are made with CBD oil that has been isolated to only contain the delta-8 THC compound. Delta-8 THC is a less psychoactive form of THC, and these gummies contain no more than 0.3% delta-9 THC.

14. Equilibria Daily Gummies

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Equilibria’s Daily Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Equilibria’s gummies are also vegan and non-GMO.

15. Exhale Wellness CBD Gummies

Image courtesy Exhale Wellness

Exhale Wellness CBD Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Exhale Wellness gummies are also vegan and non-GMO.

16. Just CBD Gummies

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Just CBD Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Just CBD’s gummies are also vegan and non-GMO.

17. CBDfx Gummies

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CBDfx Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. CBDfx’s gummies are also vegan and non-GMO.

18. Budpop CBD + Ashwagandha Gummies

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Budpop CBD + Ashwagandha Gummies are made with full spectrum CBD oil and ashwagandha extract, and contain no artificial flavors or colors. Each gummy contains 25mg of CBD, and there are 30 gummies per bottle. Budpop’s gummies are also vegan and non-GMO.

19. Cheef Botanicals CBD Gummy Cubes

Image courtesy Cheef Botanicals

Cheef Botanicals CBD Gummy Cubes are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Cheef Botanicals’ gummies are also vegan and non-GMO.

20. Hollyweed CBD Cube Gummies

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Hollyweed CBD Cube Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Hollyweed’s gummies are also vegan and non-GMO.

21. Fab CBD Gummies

Image courtesy Fab CBD

Fab CBD Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Fab’s gummies are also vegan and non-GMO.

22. Hemp Bombs CBD Gummies

Image courtesy Hemp Bombs

Hemp Bombs CBD Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Hemp Bombs’ gummies are also vegan and non-GMO.

23. CBDistillery 30mg Broad Spectrum CBD Anytime Gummies

Image courtesy CBDistillery

CBDistillery 30 mg Broad Spectrum CBD Anytime Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. CBDistillery’s gummies are also vegan and non-GMO.

24. Royal CBD Broad Spectrum CBD Gummies 25 mg

Image courtesy Royal CBD

Royal CBD Broad Spectrum CBD Gummies 25 mg are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Royal’s gummies are also vegan and non-GMO.

25. Rocky River Hemp CBD Gummies

Image courtesy Rocky River

Rocky River Hemp CBD Gummies are made with full spectrum CBD oil and contain no artificial flavors or colors. Each gummy contains 25 mg of CBD, and there are 30 gummies per bottle. Rocky River Hemp’s gummies are also vegan and non-GMO.

Are there any side effects of using CBD gummies for erectile dysfunction?

CBD is thought to be safe and well-tolerated by most people. However, as with any supplement, it is always best to speak with your healthcare provider before beginning any new supplement regimen, especially if you have any underlying health conditions.

Additionally, it is important to remember that CBD products are not regulated by the FDA and so there is no guarantee of their safety or efficacy. As such, be sure to do your research before purchasing any CBD product and only buy from reputable brands.

CBD gummies are a type of edible that contains the active compound CBD. Gummies come in various shapes, sizes, and flavors, and can be infused with other compounds such as vitamins or herbs.

What options are there for using CBD for erectile dysfunction?

There are many different methods to use CBD for erectile dysfunction. While we focused on CBD gummies today, here are some other options that may be suitable for your situation:

Topical Oils and CBD Infused Lubricants

These type of CBD products are applied to your penis so that the CBD can penetrate into your skin. This will help promote blood flow to your male genitalia and in turn help you get a hard erection. It’s best to read the instructions and ingredients on each of the topical CBD options for erectile dysfunction before buying one.

You won’t want to have any that include harmful additives that could create a sensitivity or rash on your penis. This could set you up for much more issues than just trying to deal with ED.

Another option for using CBD for erectile dysfunction is to try CBD liquid oils, CBD gum, CBD creams, and of course the best CBD gummies for erectile dysfunction featured here today.

There are three types of CBD oils on the market, this includes the oil used for the CBD gummies we shared in our list above:

Isolate CBD: This is 100% straight up CBD with no other cannabis products in it.

Broad-spectrum CBD: This option includes CBD and other cannabinoids but will not included THC.

Full-Spectrum CBD: This option for consuming CBD to help with erectile dysfunction includes CBD, all other cannabinoids and may include .3% or less of THC.

Some people prefer using the broad spectrum or full spectrum CBD gummies as they contain other cannabinoids so that you’re able to experience the entourage effect.

The entourage effect refers to the phenomenon where the combination of cannabinoids, terpenes, and flavonoids creates a more potent product than CBD alone. This is because each component works together to create a synergistic effect.

How many CBD gummies for erectile dysfunction should I eat?

The optimal dose depends on your weight, metabolism, and the severity of your pain or anxiety. A general rule of thumb is to start with the lowest possible dose and increase gradually as needed. Most people find relief with 10-20 mg of CBD per day.

What are some other tips about using CBD gummies safely?

Here are a few tips to help you use CBD gummies safely:

Start with a low dose and increase gradually as needed.

Most people find relief with 10-20 mg of CBD per day.

If you’re taking other medications, be sure to talk to your doctor about potential interactions.

CBD can affect how your body metabolizes other medications, so it’s important to stay informed and adjust your dose accordingly.

CBD may cause drowsiness or drowsiness in some people. If this is the case, avoid operating heavy machinery or driving.

Where should I store my CBD gummies?

CBD gummies should be stored in a cool, dry place away from direct sunlight.

How long do CBD gummies last?

CBD gummies have a shelf life of 6 months to 1 year. Once opened, they should be consumed within 3 months.

Final Thoughts on the 25 Best CBD Gummies for Erectile Dysfunction

It’s frustrating, embarrassing, and hard on your relationship when you have to deal with ED. If you’re experiencing this condition then you must talk to a healthcare provider such as one that specializes in erectile dysfunction.

They will be able to determine if you have an underlying condition causing this problem and be more helpful towards guiding you forward with a solution. You’re more than welcome to try the best CBD gummies for erectile dysfunction featured her as the worst case scenario they ease your stress and don’t help with ED.

Either way, CBD gummies have shown some success in being a natural treatment option for erectile dysfunction. Even though there isn’t a ton of research out there to go by to confirm this works for everyone, we’re confident it’s a positive step forward in trying to handle your ED so that you can have a healthy long term relationship.

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CBD and Viagra (Sildenafil) Interactions: Do They Mix?

CBD (or cannabidiol) is primarily used for anxiety, depression, chronic pain, and sleep — but it also offers a wide range of other therapeutic effects.

Some people report increased effectiveness of sildenafil (Viagra) after taking CBD oil — helping improve erection and reduce worries linked to performance anxiety.

But can you safely take CBD oil with Viagra?

That’s the question we’ll answer in this article.

Does CBD Interact with Sildenafil?

Yes, and you should exercise caution when taking CBD oil with sildenafil (Viagra).

The main danger of combining CBD with Viagra is associated with an increased risk of side effects. Although uncommon, Viagra can trigger indigestion, dizziness, headaches, and priapism — a condition involving painful and long-lasting erections.

CBD may also extend the effects of Viagra by slowing down its metabolism.

Types of Interactions Between CBD and Viagra (Sildenafil)

CBD’s ability to inhibit the activity of liver enzymes creates a risk of negative interactions because it alters drug metabolism.

You can experience two types of interactions between CBD and Viagra depending on the dosage.

A) Agonistic Interaction (Increased Effect)

An agonistic interaction occurs when two compounds have the same effects on the body. When it comes to taking CBD and sildenafil together, they share the ability to relax blood vessels. Combined doses of both substances may lead to excessive relaxation, including headaches, dizziness, fatigue, and the aforementioned priapism.

B) Slowed Elimination (Metabolic Inhibition)

Drugs are metabolized in the body through special enzymes known as the Cytochrome P450 (CYP450) family.

Metabolic inhibition is triggered when two drugs target the same enzymes — leading to competitive interactions. In other words, taking CBD with Viagra could result in slowing down the metabolism of one of the drugs.

Sildenafil uses CYP450 enzymes, specifically CYP3A4 (major route) and CYP2C9 (minor route). CBD is a potent inhibitor of these enzymes.

If you take CBD with sildenafil, the plasma levels of the drug can increase in the body. When you use viagra on a daily basis, the continuous buildups of the substance could become dangerous.

You can avoid it by spacing out the time between your doses so that your body can flush them.

Other Names for Viagra (Sildenafil)

Sildenafil is an umbrella term for a pharmaceutical compound that is used to treat erectile dysfunction.

It has many different brand names, such as:

  • Alsigra
  • Aryagra
  • Caverta
  • Edegra
  • Giagra
  • Medigra
  • Penegra
  • Revatio
  • Silagra
  • Vega
  • Vizarsin
  • Xcite
  • Zenegra

Does CBD Oil Interact with Other Erectile Dysfunction Medications?

In general, always look out for unintended interactions between CBD and other medications. Since CBD and erectile dysfunction medications (PDE5 inhibitors) are metabolized by the same enzymes, they share a similar risk for interaction.

The following medications can negatively interact with CBD:

  • Avanafil (Stendra)
  • Mirodenafil (Mvix)
  • Tadalafil (Cialis)
  • Udenafil (Zydena)
  • Vardenafil (Levitra, Staxyn, and Vivanza)

Is It Safe to Take CBD Oil Together With Viagra?

There are no clinical reports of dangerous side effects caused by interactions between CBD oil and Viagra.

However, it’s wise to maintain caution with one side effect (priapism). Since both substances can relax blood vessels, you’re theoretically at a higher risk of developing this condition.

If you notice any distressing reactions after taking CBD oil with sildenafil, discontinue the use and contact your doctor immediately.

Is CBD a Good Alternative to Viagra (Sildenafil?)

CBD isn’t considered a viable alternative to Viagra because it’s not an acknowledged ED treatment.

CBD and other cannabinoids have demonstrated benefits for ED in some individuals, but this effect is more related to CBD’s impact on anxiety disorders, such as performance anxiety.

VIagra, on the other hand, directly relaxes blood vessels, pumping more blood to the penis. This effect hasn’t been observed in studies investigating the effects of CBD.

If you experience mild ED caused by anxiety, CBD could be a safer alternative to viagra. However, ED triggered by mechanical injuries is unlikely to benefit from CBD.

What is Viagra?

Viagra is one of the brand names for sildenafil — a phosphodiesterase type 5 (PDE5) inhibitor. Doctors prescribe it to treat erectile dysfunction and pulmonary hypertension.

It’s an FDA-approved treatment for ED and is available only for a prescription in most countries.

Viagra (Sildenafil) Details:

Pharmaceutical Name Sildenafil
Brand Names Viagra, Silagra, Alsigra, Aryagra, Edegra, Revatio, Penegra, Xcite, Vega, Giagra, Vizarsin, Zenegra, Caverta
Class of Drug Phosphodiesterase 5 Inhibitor
Metabolic Enzymes Cyp 450 enzymes (CYP3A4 and CYP2C9)
Interaction with CBD Agonistic, metabolic inhibitor
Strength of Interaction Low

How Does Viagra Work for Erectile Dysfunction (ED)?

Sildenafil (Viagra) is the inhibitor of phosphodiesterase 5 (PDE5). Its main mechanism causes an increase in the blood flow to a flaccid penis. This feature enables erection.

PDE5 is an enzyme commonly found in vascular smooth muscles, visceral smooth muscles, platelets, and cavernosa.

Was Viagra Always Used to Treat ED?

Viagra was originally meant to serve a different purpose. It was invented as a potential blood pressure medication. Its side effect, however, made it a preferred drug for ED.

The Mechanism Behind Erection

When you have sex with your partner, an adequate amount of foreplay should lead to a release of nitric oxide (NO) from the nerves and endothelial cells. This event triggers the release of cyclic guanosine monophosphate (cGMP).

The cGMP’s release relaxes the muscles of corpora cavernosa in the penis, dilating the blood vessels. As the blood flows rapidly into those vessels, the penis becomes enlarged and gets erect. This state lasts until the end of the sexual intercourse or after ejaculation.

What Happens When You Take Viagra

The enzyme PDE5 blocks the additional blood flow to the vessels in the penis. It does so by causing the cGMP levels to degrade. In the majority of ED patients, the dysfunction also affects the blood vessels in the penis.

Since Viagra inhibits PDE5 and increases the level of cGMP, it lets more blood flow into the penis, allowing for a successful erection.

With a positive mindset and sufficient sexual stimulation, this drug may be even more effective.

Viagra isn’t recommended for use alongside alcohol. Patients with severe heart disease, priapism, several renal and liver disease, blood disorders, retinitis pigmentosa, and hypersensitivity to sildenafil should steer away from viagra, too.

Although Viagra doesn’t cause dependence and addiction, it can interact with several medications, including antacids, guanylate cyclase stimulators, CYP3A4 inducers, and CYP3A4 inhibitors.

Side Effects of Viagra

  • Abdominal pain
  • Abnormal vision
  • Back pain
  • Diarrhea
  • Dyspepsia
  • Hot flushes
  • Headaches
  • Loss of vision
  • Nausea
  • Skin Rash
  • Muscle pain
  • Bluish tinted vision
  • TIngling sensation in the limbs

What is CBD Oil?

CBD oil is an oily extract derived from cannabis. It can be extracted from hemp and marijuana, but most CBD oils on the market come from hemp. That’s because hemp is legal in all 50 states.

CBD doesn’t get you high, but it comes with a myriad of health benefits. This feature makes CBD an appealing alternative to marijuana. Since THC can make users anxious in higher doses, some of them are afraid of starting the treatment. CBD comes in handy here.

Since CBD is fat-soluble, manufacturers suspend it in a carrier oil. Usually, it’s MCT oil because it contains the highest percentage of saturated fatty acids.

People commonly use CBD oil for pain relief or to reduce anxiety, depression, and sleep problems. However, CBD also has the potential to manage the symptoms of autoimmune diseases and neurological conditions.

In a 2009 article published in the journal Annals of the New York Academy of Sciences, the authors concluded that the endocannabinoid receptors occur in the sexual reproductive organs, such as testicles. They also found them in the brain.

Other studies found that cannabinoids such as CBD and THC may increase libido and improve sex life in general, while others warn that regular cannabis use may lower sex drive in males. However, these studies also involved high-THC cannabis (marijuana).

One of the best-researched areas of the therapeutic use of CBD is anxiety. CBD may improve libido by reducing anxiety disorders, such as performance anxiety — increasing one’s desire for sex.

Final Verdict: Can You Take CBD Oil with Viagra?

CBD can inhibit the metabolism of Viagra in the body — potentially increasing the duration and concentration of the drug in the body.

In addition, CBD may strengthen some of the effects of Viagra, increasing the risk of lightheadedness and painful erection.

Always talk to your doctor before taking CBD oil with Viagra. Doing so will help you find the right dosage and timing for both products and avoid potential interactions.

Sources:

  1. Carvalho, R. K., Andersen, M. L., & Mazaro‐Costa, R. (2020). The effects of cannabidiol on male reproductive system: A literature review. Journal of Applied Toxicology, 40(1), 132-150.
  2. Pizzol, D., Demurtas, J., Stubbs, B., Soysal, P., Mason, C., Isik, A. T., … & Veronese, N. (2019). Relationship between cannabis use and erectile dysfunction: a systematic review and meta-analysis. American journal of men’s health, 13(6), 1557988319892464.
  3. Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825-836
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Livvy Ashton

Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.

Does CBD Interact With Sildenafil (Viagra)?

Cannabidiol or CBD may prolong the effects of sildenafil (Viagra) — but is this combination safe? What are the risks?

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Sildenafil (Viagra) is used in the treatment of erectile dysfunction (ED).

Cannabidiol (AKA CBD) is primarily used to manage chronic pain, anxiety, or insomnia — but it has many other health benefits as well.

Some people report using CBD alongside sildenafil to boost its effects — helping to increase erectile function and eliminate concomitant issues like performance anxiety.

Is this combination safe? What are the risks of taking CBD with Viagra (sildenafil)?

Table of Contents

Does CBD Interact With Sildenafil (Viagra)?

Yes. CBD can interact with sildenafil (Viagra) and should be used with caution.

The main concern with using CBD and Viagra is an increased risk of side effects. While uncommon, Viagra can lead to headaches, dizziness, indigestion, and a condition called priapism which involves painful and long-lasting erections.

CBD may also prolong the effects of Viagra by slowing down the body’s ability to eliminate it.

Let’s explore each type of interaction more closely.

A) Slowed Elimination (Metabolic Inhibition)

Drug metabolism occurs in the body due to the effects of a group of enzymes from the P450 family. Metabolic inhibition occurs when two drugs need the same enzymes to get metabolized. Hence, they end up competing against each other for the said enzymes. This action could result in slowing down the metabolism of one or both drugs.

Sildenafil is extensively metabolized by CYP450 enzymes, especially CYP3A4 (major route) and CYP2C9 (minor route). CBD also gets metabolized by these same enzymes.

Because of this ability, if CBD and sildenafil are taken together, the plasma levels of sildenafil can rise in the body. This only becomes dangerous if Viagra is used continuously on a daily basis. Over time, concentrations of the drug can build up to dangerous levels. It’s important to allow enough time between doses for it to be cleared from the body.

B) Increased Effect (Agonistic Interaction)

An agonistic interaction occurs when two or more items exhibit the same effect on the body.

In the case of CBD and sildenafil, the shared effect focuses on blood vessel dilation. Both CBD and sildenafil cause the blood vessels to relax. This could lead to symptoms of excessive relaxation, which include dizziness, headaches, and priapism.

Other Names For Sildenafil(Viagra)

Sildenafil is sold under many different names. All share the same risk and potential interactions.

Other names for sildenafil include:

  • Alsigra
  • Aryagra
  • Caverta
  • Edegra
  • Giagra
  • Medigra
  • Penegra
  • Revatio
  • Silagra
  • Vega
  • Vizarsin
  • Xcite
  • Zenegra

Similar Medications: CBD & Erectile Dysfunction Medications

CBD and erectile dysfunction medications (PDE5 inhibitors) all carry the same level of risk for interaction. Most ED medications work through the same mechanism and require metabolism by the same enzymes in the liver.

Here’s a list of similar medications that share a similar level of risk when combined with CBD:

Is It Safe to Take CBD & Sildenafil (Viagra) Together?

The interaction between sildenafil and CBD is considered mild.

However, because of the severity of one side effect in particular (priapism), it’s wise to speak to your doctor before taking CBD alongside your prescription Viagra.

To further reduce your chances of experiencing interactions, it’s wise to separate the doses of each substance by about 2 hours.

If you experience any problems or concerns, contact your physician immediately.

Is CBD A Viable Alternative to Sildenafil (Viagra)?

CBD is not considered a viable alternative to sildenafil.

Cannabidiol and other cannabinoids have been shown to improve ED in some individuals, but this effect relies more heavily on the effects of CBD for reducing anxiety conditions (such as performance anxiety).

Sildenafil targets the blood vessels directly feeding blood flow to the penis. This effect is not found in studies exploring the effects of CBD.

For people who may be experiencing mild forms of ED or could trace the cause of their ED to anxiety, CBD could be a safer alternative. However, people who experience ED as a result of mechanical dysfunctions are unlikely to find CBD even remotely as effective for managing symptoms as sildenafil.

What is Sildenafil (Viagra)?

Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor. Viagra is one of its brand names. It’s used in the treatment of erectile dysfunction and pulmonary hypertension.

It is an FDA-approved drug and is sold as a prescription-only drug in most countries.

Sildenafil (Viagra) Specs:

Drug Name Sildenafil
Trade Names Viagra, Silagra, Alsigra, Aryagra, Caverta, Edegra, Giagra, Medigra, Penegra, Vega, Xcite, Zenegra, Revatio, Vizarsin
Classification Phosphodiesterase 5 inhibitor
CYP Metabolism CYP450 enzymes, especially CYP450 3A4(major route) and CYP2C9 (minor route)
Interaction With CBD Metabolic inhibitor, Agonistic
Risk of Interaction Mild

What Does Sildenafil (Viagra) Do?

Sildenafil works by inhibiting phosphodiesterase 5 (PDE5). Its main action is to increase the blood flow to a flaccid penis. This ability causes it to get erect. Sildenafil does this by inhibiting an enzyme called phosphodiesterase type 5 (PDE5). PDE5 is commonly found in corpora cavernosa, vascular smooth muscles, visceral smooth muscles, and platelets.

Originally developed as a potential blood pressure medication, sildenafil’s ability to cause erection in patients with erectile dysfunction was accidental but a very welcome one. This discovery caused it to become one of the most valuable methods to treat ED.

Generally, in sexual intercourse, after an adequate amount of foreplay, there will be a release of nitric oxide (NO) from nerve terminals and endothelial cells. This action releases cyclic guanosine monophosphate (cGMP) too.

The cGMP’s release causes the muscles of corpora cavernosa in the penis to relax and the blood vessels to get dilated. It leads to a rapid entry of blood into those vessels, causing the penis to engorge, grow large, and get erect. The penis stays so until the end of the intercourse and until after ejaculation occurs.

The enzyme PDE5 prevents blood vessels in the penis from relaxing. It does this by causing the degradation of cGMP. In most ED patients, the blood vessels in the penis are also affected and lose their ability to relax properly or have some obstructions in them.

Sildenafil inhibits PDE5, increases the level of cGMP in the corpus cavernosum, allows more blood to flow into the penis, and causes the penis to get erect long enough to have sex.

However, sildenafil needs proper sexual stimulation to do its work. With a relaxed mind and good sexual stimulation, this drug may work even better.

Apart from the presence of PDE5 in the corpus cavernosum of the penis, PDE5 is also present in the pulmonary vasculature. Hence, sildenafil can increase cGMP within pulmonary vascular smooth muscle cells and cause them to relax. In patients with pulmonary arterial hypertension, this can lead to vasodilation of the pulmonary vascular bed and systemic circulation.

It is not recommended for use in women and children. Sildenafil does not cause dependence and addiction. This drug may show mild to dangerous interactions when combined with some medications. These include nitrates, antihypertensive medications, guanylate cyclase stimulators, antacids, CYP3A4 inhibitors, and CYP3A4 inducers. Sildenafil should not be used with these medications.

Sildenafil is not recommended for consumption alongside alcohol of any form. It must be avoided in users with severe heart disease, hypersensitivity to sildenafil, priapism, severe renal and liver disease, stomach ulcers, retinitis pigmentosa, and blood disorders.

Side Effects of Sildenafil (Viagra)

  • Headaches
  • Tingling sensation in the limbs and extremities
  • Hot flushes
  • Abdominal pain
  • Bluish tinted vision
  • Loss of vision
  • Sensitivity to light
  • Nasal blockage
  • Back pain
  • Nausea
  • Abnormal vision
  • Skin rash
  • Dyspepsia
  • Diarrhea
  • Muscle pain
  • Prolonged and painful erection

Key Takeaways: Is it Safe to Take Sildenafil (Viagra) With CBD?

CBD can slow down the metabolism of sildenafil in the body — potentially causing it to remain active in the body for a longer duration.

Additionally, CBD may potentiate some of the effects of Viagra, leading to a higher risk of side effects (especially dizziness and priapism).

Always consult with your doctor before taking CBD if you’ve been given a prescription for Viagra or another version of sildenafil (the active ingredient in Viagra).

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